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- Ben Stiller as Tugg Speedman
- Jack Black as Jeff Portnoy
- Robert Downey Jr. as Kirk Lazarus
- Jeremy Irons as Four Leaf Tayback
- Steve Coogan as Damien Cockburn
- Jay Baruchel as Kevin Sandusky
- John Goodman as Cody
- Eddie Murphy as Alpha Chino
- Daniel Radcliffe as Rob Slolom
- Brandon Soo Hoo as Tran
- Jude Law as Rick Peck
- Tom Cruise as Les Grossman